TABLETS
Are Unit dosage form, tamperproof solid dosage form. 
Manufacture of Granulations
Direct 
Compression
e.g. NaCl, KBr etc. 
Compression granulation Wet granulation
Direct compression: Some crystalline substances which can be compressed directly. A directly compressible 
diluents added e.g. microcrystalline cellulose. 
Disadvantages:
9 Differences in particle size & bulk density between drug & diluents leads to stratification within granulation 
resulting in poor content of uniformity of drug in compressed tablet. 
9 In direct compression diluents may interact with the drug e.g. Milard’s reaction that is yellow discolouration
between amine groups and hydrous lactose.
9 Because of dry nature of direct compression a static charge develops which may prevent uniform distribution of 
drug in the granulation.
9 The maximum percentage of non compressible content in direct compression can be upto 30%.
Compression granulations: Used when drug is sensitive to heat, moisture (wet granulations) e.g. vitamins, aspirin 
etc. 
Powder blend slugs 
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Screened or milled to produce granular form
Equipments:
1. Roller Compactor 
2. Chilsonator 
3. Hut’s compactor